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黄建东 Jiandong Huang
Jiandong Huang
Email: jd.huang@giat.ac.cn
联系电话: +86-20-22912760
传真: +86-20-22912525
地址:广东省广州市南沙区海滨路1121号A栋407
  • 简介

  • 出版物

    个人介绍

    I am a reader in neuroprosthesis. I lead a strongly interdisciplinary team and my main interest is in optoelectronic/optogenetic visual prosthesis and visual aid systems for the blind. I was previously a senior lecturer at Imperial College, where I also held and RCUK fellowship. Prior to this, I did two post-doc tours of duty at Imperial College (2002-2005), and worked for a year in the software industry (2001-2002). I have a Ph.D. in Bioelectronics from the Japan Advanced Institute of Science and Technology, and an MRes and BSc in Applied Physics from Liverpool University


    学位资历

    Ph.D., Biochemistry, Department of Chemistry and Biochemistry-University of California, Los Angeles, USA
    B.S., Genetics and Genetic Engineering-Fudan University, China
    工作经历

    1989-1990Teaching Assistant, Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA
    1990-1994Research Assistant, Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA
    1994-1998Postdoctoral Research Fellow, ABL-Basic Research Program, National Cancer Institute-FCRDC, NIH, USA, Under the supervision of Drs. Nancy A. Jenkins and Neal G. Copeland
    1998-2006Assistant Professor, Department of Biochemistry, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China
    2006-Associate Professor with Tenure, Department of Biochemistry, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China
    1999-Visiting Professor, the Fourth Military Medical University, Xi’An, China
    2004.10-2006.9Adjunct Professor, Shenzhen Graduate School, Peking University
    2006 – 2011Visiting Professor, Institute of Microbiology and Infectious Disease, Academy of Military Medical Sciences, Beijing, China
    会员资格

    2001-Member of Asia-Pacific International Molecular Biology Network (IMBN)
    • 1.Jian-Dong Huang, Lin Leng, and Xian-shu Wang (December, 1987). Cell Surface DNA. Progress in Biochemistry and Biophysics生物化學與生物物理進展. V6: 23-25. (IF= 0.215, (2005))

    • 2.Albert J. Courey and Jian-Dong Huang (March, 1995). The Establishment and Interpretation of Transcription Factor Gradients in the Drosophila Embryo. Biochimica Et Biophysica Acta-Gene Structure And Expression. V1261 N1: 1-18. (IF= 2.506, (2005))

    • 3.Hsiang-fu Kung and Jian-Dong Huang (February, 2001). The mouse model and human disease. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao中國醫學科學院學報), V23 (1): 2-7 [Abstract]

    • 4.Hsiang-fu Kung and Jian-Dong Huang (March, 2001). The mouse model and human disease (Sequel). Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao中國醫學科學院學報), V23 (2): 97-102

    • 5.Hsiang-fu Kung and Jian-Dong Huang (April, 2001). The mouse model and human disease (Sequel): Cancer. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao中國醫學科學院學報), V23 (3): 205-209

    • 6.Jian-Dong Huang (February 2008) The Huang Laboratory. BioTechniques, V44(2): 173

    • 7.Sui Cheung Man, Siva Sundara Kumar Durairajan, Wan Fung Kum, Jia Hong Lu, Jian-Dong Huang, Ching Fung Cheng, Vincent Chung, Min Xu and Min Li (June 2008) Systematic Review of the Efficacy and Safety of Herbal Medicines for Alzheimer's Disease. Journal of Alzheimer's Disease V14(2): 209-223

    • 8.Duojia Pan, Jian-Dong Huang, and Albert J. Courey (October, 1991). Functional Analysis of the Drosophila Twist Promoter Reveals a Dorsal-Binding Ventral Activator Region. Genes and Development, V5 (10): 1892-1901. [Abstract] [PDF] (IF= 16.385, (2004))

    • 9.Jian-Dong Huang, Deborah H. Schwyter, Jill M. Shirokawa, and Albert J. Courey (April, 1993). The Interplay Between Multiple Enhancer and Silencer Elements Defines the Pattern of Decapentaplegic Expression. Genes & Development, V7 (4): 694-704. [Abstract] [PDF] (IF= 16.385, (2004))

    • 10.Deborah H. Schwyter, Jian-Dong Huang, Todd Dubnicoff, and Albert J. Courey (July, 1995). The Decapentaplegic Core Promoter Region Plays an Integral Role in the Spatial Control of Transcription. Molecular and Cellular Biology. V15 (7): 3960-3968. [Abstract] [PDF] (IF= 7.822, (2004))

    • 11.Gwo-Jen Liaw, Karen M. Rudolph, Jian-Dong Huang, Todd Dubnicoff, Albert J. Courey, and Judith A. Lengyel (December, 1995). The torso response element binds GAGA and NTF-1/Elf-1, and regulates tailless by relief of repression. Genes & Development, V9 (24): 3163-76. [Abstract] [PDF] (IF= 16.385, (2004))

    • 12.Jian-Dong Huang, Todd Dubnicoff, Gwo-Jen Liaw, Yijian Bai, Scott A. Valentine, Jill M. Shirokawa, Judith A. Lengyel, and Albert J. Courey (December, 1995). Binding Sites For Transcription Factor NTF-1/Elf-1 Contribute To The Ventral Repression Of Decapentaplegic. Genes & Development, V9 (24): 3177-89. [Abstract] [PDF] (IF= 16.385, (2004))

    • 13.Jian-Dong Huang, M. Jamie T. V. Cope, Valerie Mermall, Marjorie C. Strobel, John Kendrick-Jones, Liane B. Russell, Mark S. Mooseker, Neal G. Copeland, and Nancy A. Jenkins (April, 1998). Molecular Genetic Dissection of Mouse Unconventional Myosin-VA: Head Region Mutations. Genetics, V148 (4): 1951-1961. [Abstract] [Full text] [PDF] (IF= 4.289, (2005))

    • 14.Jian-Dong Huang,Valerie Mermall, Marjorie C. Strobel, Liane B. Russell, Mark S. Mooseker, Neal G. Copeland and Nancy A. Jenkins (April, 1998). Molecular Genetic Dissection of Mouse Unconventional Myosin-VA: Tail Region Mutations. Genetics, V148 (4): 1963-1972. [Abstract] [Full text] [PDF] (IF= 4.289, (2005))

    • 15.Jian-Dong Huang, Scott T. Brady, Bruce W. Richards, David Stenoien, James H. Resau, Neal G. Copeland & Nancy A. Jenkins (January, 1999). Direct interaction of microtubule- and actin-based transport motors. Nature, V397: 267-270 [Abstract] [Full text] [PDF] (IF= 32.182, (2004))

    • 16.Julie M. Jones, Jian-Dong Huang, Valerie Mermall, Bruce A. Hamilton, Mark S. Mooseker, Andrew Escayg, Neal G. Copeland, Nancy A. Jenkins and Miriam H. Meisler, (March, 2000). The mouse neurological mutant flailer results from exon shuffling between Gnb5 and Myo5a to generate a novel hybrid gene. Human Molecular Genetics, V9 (5): 821-828 [Abstract] [Full text] [PDF] (IF=7.801, (2004))

    • 17.Josephine Sui-Yan Au and Jian-Dong Huang (October, 2002). A tissue specific exon of Myosin Va is responsible for selective cargo binding in melanocytes. Cell Motility and the Cytoskeleton, V53 (2): 89-102 [Abstract] [Full text] [PDF] (IF=3.068, (2004))

    • 18.Xin-Mei Zhang and Jian-Dong Huang (August, 2003). Combination of overlapping bacterial artificial chromosomes by a two-step recombinogenic engineering method. Nucleic Acids Research, V31 (15): e81 [Abstract] [Full text] [PDF] (IF=7.552, (2005))

    • 19.Julian A. Tanner, Rory M. Watt, Yu-Bo Chai, Lin-Yu Lu, Marie C. Lin, J. S. Malik Peiris, Leo L. M. Poon, Hsiang-Fu Kung, and Jian-Dong Huang (October, 2003). The Severe Acute Respiratory Syndrome (SARS) Coronavirus NTPase/Helicase Belongs to a Distinct Class of 5’ to 3’ Viral Helicases. Journal of Biological Chemistry, V278 (41): 39578-39582. First Published on August 13, 2003 as Accelerated Publications; doi:10.1074/jbc.C300328200 [Abstract] [Full Text] [PDF] Supplemental Data (IF=6.355, (2004))(通讯作者)

    • 20.Liu Yang (楊柳), Zhoujing Luo (羅卓荊), Qiang Ji (頡強), Xiaobing Jin (靳小兵), Danny Chan, Wing-Sum Hui, Jian-Dong Huang, Kenneth M.C. Cheung, Kathryn S.E.Cheah (October, 2003). Culture of chondrocytes of hereditary multiple exostosis in vitro. Chinese Journal of Clinical Rehabilitation, V7 (26): 3590-3591

    • 21.Xin-tian Li, Nina Costantino, Lin-yu Lu, De-pei Liu, Rory M. Watt, Kathryn S. E. Cheah, Donald L. Court and Jian-Dong Huang (November, 2003). Identification of factors influencing strand bias in oligonucleotide–mediated recombination in E. coli. Nucleic Acids Research, V31 (22): 6674-6687. [Abstract] [Full Text] (IF=7.552, (2005))(Faculty of 1000: evaluations for Li XT et al Nucleic Acids Res 2003 Nov 15 31 (22) :6674-6687 http://www.f1000biology.com/article/14602928/evaluation)

    • 22.Xin-Mei Zhang, Alam Hoi-Lam Ng, Julian A. Tanner, Wu-Tian Wu, Neal G. Copeland, Nancy A. Jenkins, and Jian-Dong Huang (September, 2004). Highly Restricted Expression of Cre Recombinase in Cerebellar Purkinje Cells. genesis: The Journal of Genetics and Development (formerly Developmental Genetics), V40: 45-51. [Abstract] [PDF] (IF=2.491, (2004))

    • 23.Richard Y. Kao, Wayne H.W. Tsui, Terri S.W. Lee, Julian A. Tanner, Rory M. Watt, Jian-Dong Huang, Lihong Hu, Guanhua Chen, Zhiwei Chen, Linqi Zhang, Tian He, Kwok-Hung Chan, Herman Tse, Amanda P.C. To, Louisa W.Y. Ng, Bonnie C.W. Wong, Hoi-Wah Tsoi, Dan Yang, David D. Ho, and Kwok-Yung Yuen (September, 2004). Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics. Chemistry & Biology, V11 (9): 1293-1299. [Abstract] [Full Text] [PDF] (IF=5.725, (2004))

    • 24.T. Norene O’Sullivan, Xufeng S. Wu, Rivka A. Rachel, Jian-Dong Huang, Deborah A. Swing, Lydia E. Matesic, John A. Hammer III, Neal G. Copeland, and Nancy A. Jenkins (November, 2004) dsu Functions in a MYO5A-Independent Pathway to Suppress the Coat Color of Dilute Mice. Proceedings of the National Academy of Sciences, V101 (48): 16831-16836. [Abstract] [Full Text] [PDF] (IF= 10.452, (2004))

    • 25.Andrea Bernini, Ottavia Spiga, Arianna Ciutti, Stefano Chiellini, Luisa Bracci, Xiyun Yan, Bojian Zheng, Jian-Dong Huang, Ming-Liang He, Huai-Dong Song, Pei Hao, Guoping Zhao, Neri Niccolai (December, 2004) Prediction of Quaternary Assembly of SARS Coronavirus Peplomer. Biochemical and Biophysical Research Communications, V325 (4): 1210-1214. [Abstract] [Full Text] [PDF] (IF= 3.000, (2005))

    • 26.Xue-Song Wu, Li Xin, Wen-Xuan Yin, Xi-Ying Shang, Lu Lu, Rory M. Watt, Kathryn S. E. Cheah, Jian-Dong Huang, De-Pei Liu, and Chih-Chuan Liang (February, 2005). Increased Efficiency of Oligonucleotide-Mediated Gene Repair Through Slowing Replication Fork Progression. Proceedings of the National Academy of Sciences, V102(7): 2508–2513 [Abstract] [Full Text] [PDF] (IF= 10.452, (2004))

    • 27.Julian A. Tanner, Bo-Jian Zheng, Jie Zhou, Rory M. Watt, Jie-Qing Jiang, Kin-Ling Wong, Yong-Ping Lin, Lin-Yu Lu, Ming-Liang He, Hsiang-Fu Kung, Andreas J. Kesel, and Jian-Dong Huang (March, 2005). The Adamantane-Derived Bananins are Potent Inhibitors of the Helicase Activities and Replication of SARS Coronavirus, Chemistry & Biology, V12: 303-311 [Summary] [Full Text] [PDF] [Supplemental Data] (IF=5.725, (2004))

    • 28.Queenie N. Y. Wong, Vivian C. W. Ng, Marie C. M. Lin, Hsiang-fu Kung, Danny Chan and Jian-Dong Huang (March, 2005). Efficient and Seamless DNA Recombineering using a Thymidylate Synthase A Selection System in Escherichia coli, Nucleic Acids Research, V33(6), e59 [Abstract] [Full Text] [PDF] (IF=7.552, (2005))

    • 29.Matthew J. Tyska, Andrew T. Mackey, Jian-Dong Huang, Neil G. Copeland, Nancy A. Jenkins, and Mark S. Mooseker (May, 2005). Myosin-1a Is Critical for Normal Brush Border Structure and Composition, Molecular Biology of the Cell, V16(5): 2443-2457 [Abstract] [Full Text] [PDF] (IF= 7.517, (2004))

    • 30.Bo-Jian Zheng*, Yi Guan, Ming-Liang He, Hongzhe Sun, Lanying Du, Ying Zheng, Kin-Ling Wong, Honglin Chen, Ying Chen, Linyu Lu, Julian A Tanner, Rory M Watt, Neri Niccolai, Andrea Bernini, Ottavia Spiga, Patrick CY Woo, Hsiang-fu Kung, Kwok-Yung Yuen and Jian-Dong Huang* (2005). Synthetic Peptides Outside the Spike Protein Heptad Repeat Regions as Potent Inhibitors of SARS-Associated Coronavirus, Antiviral Therapy, V10(3): 393-403 (* co-corresponding author) [Abstract] [PDF] (IF= 6.036, (2004))

    • 31.Baohua Liu, Jianming Wang, Kui Ming Chan, Wai Mui Tjia, Wen Deng, Xinyuan Guan, Jian-Dong Huang, Kai Man Li, Pui Yin Chau, David J Chen, Duanqing Pei, Alberto M Pendas, Juan Cadi?anos, Carlos López-Otín, Hung Fat Tse, Chris Hutchison, Junjie Chen, Yihai Cao, Kathryn S E Cheah, Karl Tryggvason & Zhongjun Zhou (July, 2005). Genomic Instability in Laminopathy-based Premature Aging, Nature Medicine, V11(7): 780-785. [Abstract] [Full Text] [PDF] (IF= 31.223, (2004))(Faculty of 1000 Biology: evaluations for Liu B et al Nat Med 2005 Jul 11 (7) :780-5 http://www.f1000biology.com/article/id/1026680/evaluation)

    • 32.Wen-Xuan Yin, Xue-Song Wu, Guang Liu, Zhu-Hong Li, Rory M. Watt, Jian-Dong Huang, De-Pei Liu, Chih-Chuan Liang (September, 2005). Targeted correction of a chromosomal point mutation by modified single-stranded oligonucleotides in a GFP recovery system. Biochemical and Biophysical Research Communications, V334(4):1032-1041, [Abstract] [Full Text] [PDF] (IF= 3.000, (2005))

    • 33.Xin-Mei Zhang, Bai-Yu Chen, Alam Hoi-Lam Ng, Julian A. Tanner, David Tay, Kwok-Fai So, Rivka A. Rachel, Neal G. Copeland, Nancy A. Jenkins, and Jian-Dong Huang (October, 2005) Transgenic Mice Expressing Cre-Recombinase Specifically in Retinal Rod Bipolar Neurons. Investigative Ophthalmology & Visual Science (IOVS) V46: 3515-3520, [Abstract] [Full Text] [PDF] (IF= 3.643, (2005))

    • 34.Ruiguang Ge, Rory M. Watt, Xuesong Sun, Julian A. Tanner, Qing-Yu He, Jian-Dong Huang* and Hongzhe Sun* (January, 2006). Expression and Characterization of the Histidine-rich Protein, Hpn: Potential for Nickel Storage in Helicobacter pylori. Biochemical Journal, V393(1): 285-293 (* co-corresponding author) [Abstract] [Full Text] [PDF] (IF= 4.278, (2004)) (Faculty of 1000 Biology: evaluations for Ge R et al Biochem J 2006 Jan 1 393 (Pt 1) :285-93 http://www.f1000biology.com/article/id/1033680/evaluation)

    • 35.Andrea Bernini, Ottavia Spiga, Vincenzo Venditti, Filippo Prischi, Luisa Bracci, Jian-Dong Huang, Julian A. Tanner, Neri Niccolai (2006 May 19, Epub 2006 Mar 23) Tertiary Structure Prediction of SARS coronavirus helicase. Biochemical and Biophysical Research Communications, V343(4):1101-1104. [Abstract] [Full Text] [PDF] (IF= 3.000, (2005))

    • 36.Ying Peng, Pai-Hao Yang, Julian A. Tanner, Jian-Dong Huang, Ming Li, Henry F. Lee, Ren-He Xu, Hsiang-Fu Kung, Marie C.M. Lin (2006 May 26, Epub 2006 Mar 24) Cold-Inducible RNA Binding Protein is Required for the Expression of Adhesion Molecules and Embryonic Cell Movement in Xenopus Laevi. Biochemical and Biophysical Research Communications, V344(1): 416-424. [Abstract] [Full Text] [PDF] (IF= 3.000, (2005))

    • 37.Ming-Liang He, Bo-jian Zheng, Ying Chen, Kin-Ling Wong, Jian-Dong Huang, Marie C. Lin, Ying Peng, Kwok Y. Yuen, Joseph J.Y. Sung, Hsiang-fu Kung (2006 May 1, Epub 2006 Mar 30) Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS associated coronavirus. FEBS Letters, V580(10): 2414-20 [Abstract] [Full Text] [PDF] (IF=3.415, (2005))

    • 38.Lanying Du, Yuxian He, Yijia Wang, Haojie Zhang, Selene Ma, Charlotte K.L. Wong, Sharon H.W. Wu, Fai Ng, Jian-Dong Huang, Kwok-Yung Yuen, Shibo Jiang, Yusen Zhou, Bo-Jian Zheng (September 15, 2006, Epub June 20, 2006) Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits neutralizing antibodies: Implication for developing SARS vaccines. Virology V353(1):6-16 [Abstract] [Full Text] [PDF] (IF=3.080, (2005))

    • 39.Ruiguang Ge, Yi Zhang, Xuesong Sun, Rory M. Watt, Qing-Yu He, Jian-Dong Huang, Dean E. Wilcox, and Hongzhe Sun (September 6, 2006). Thermodynamic and Kinetic Aspects of Metal Binding to the Histidine-rich Protein, Hpn. Journal of the American Chemical Society; (Communication), V128(35):11330-1 [Abstract] Full Text HTML | Hi-Res PDF | PDF w/ Links (IF= 7.419, (2005))

    • 40.Zai Wang, Zhong-Jun Zhou, De-Pei Liu, Jian-Dong Huang (November 24, 2006, Available online 26 September 2006). Single-Stranded Oligonucleotide-mediated gene repair in mammalian cells has a mechanism distinct from homologous recombination repair. Biochemical and Biophysical Research Communications, V350(3): 568–573. [Abstract] [Full Text] [PDF] (IF= 3.000, (2005))

    • 41.Michael S. Y. Huen, Xin-tian Li, Lin-Yu Lu, Rory M. Watt, De-Pei Liu and Jian-Dong Huang (2006 December 1, Published online 2006 November 6). The involvement of replication in single stranded oligonucleotide-mediated gene repair, Nucleic Acids Research V34(21):6183–6194; doi:10.1093/nar/gkl852 [Abstract] [FREE Full Text] [Print PDF][Screen PDF] (IF=7.552, (2005))

    • 42.Michael S.Y. Huen, Lin-Yu Lu, De-Pei Liu, Jian-Dong Huang (February 2, 2007, Available online 8 December 2006) Active transcription promotes single-stranded oligonucleotide mediated gene repair, Biochemical and Biophysical Research Communications, V353(1):33-39. [Abstract] [Full Text] [PDF] (IF= 3.000, (2005))

    • 43.Rory M. Watt, Jing Wang, Meikid Leong, Hsiang-fu Kung, Kathryn S.E. Cheah, Depei Liu, Antoine Danchin and Jian-Dong Huang (2007, Published online January 31, 2007). Visualizing the proteome of Escherichia coli: an efficient and versatile method for labeling chromosomal coding DNA sequences (CDSs) with fluorescent protein genes. Nucleic Acids Research V35(6):e37 doi:10.1093/nar/gkl1158 [Abstract] [Full Text] [Print PDF] [Screen PDF] (IF=7.552, (2005)) (Faculty of 1000 Biology: evaluations for Watt RM et al Nucleic Acids Res 2007 35 (6) :e37 http://www.f1000biology.com/article/id/1088949/evaluation)(通讯作者,网上打印)

    • 44.Ruiguang Ge, Xuesong Sun, Qing Gu, Rory M. Watt, Julian A. Tanner, Benjamin Chun Yu Wong, Harry Huaxiang Xia, Jian-Dong Huang, Qing-Yu He, and Hongzhe Sun (August 2007, Available online May 15, 2007). A Proteomic Approach for Identification of Bismuth-binding Proteins in Helicobacter pylori. Journal of Biological Inorganic Chemistry, V12(6):831-842 [Abstract] [Full Text] [PDF] (IF= 3.303, (2006)) doi: 10.1007/s00775-007-0237-7

    • 45.Nan Yang, Julian A. Tanner, Bo-Jian Zheng, Rory M. Watt, Ming-Liang He, Lin-Yu Lu, Jie-Qing Jiang, Ka-To Shum, Yong-Ping Lin, Kin-Ling Wong, Marie C. M. Lin, Hsiang-Fu Kung, Hongzhe Sun,* and Jian-Dong Huang* (2007, Published Online: 23 Jul 2007). Bismuth Complexes as Inhibitors of the SARS Coronavirus, Angewandte Chemie-International Edition, V46:6464-6468 [Abstract] [Full Text] [PDF] (* co-corresponding author) DOI: 10.1002/anie.200701021 (IF= 10.232, (2006))

    • 46.Nan Yang, Julian A. Tanner, Zai Wang, Jian-Dong Huang, Bo-Jian Zheng, Nianyong Zhu and Hongzhe Sun (November 14, 2007, First published on the web 16th August 2007). Inhibition of SARS coronavirus helicase by bismuth complexes, Chemical Communications (Camb). (42):4413-4415. [Abstract] [Full Text] [PDF] (IF= 4.521, (2006)) DOI: 10.1039/b709515e

    • 47.Xiaoping An., Jun Lu., Jian-Dong Huang*, Baozhong Zhang, Dabin Liu, Xin Zhang, Jinhui Chen, Yusen Zhou, Yigang Tong* (2007, published online November 14, 2007) Rapid assembly of multiple-exon cDNA directly from genomic DNA. PLoS ONE V2(11), e1179 [Abstract] [Full Text] [PDF] (* co-corresponding author) (IF= 4.411, (2010))

    • 48.Chen-Li Liu, Li-Xia Xie, Min Li*, Siva Sundara Kumar Durairajan, Shinya Goto, Jian-Dong Huang* (published online December 19, 2007) Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling. PLoS ONE 2(12): e1321. doi:10.1371/journal.pone.0001321 (* co-corresponding author) [Abstract] [Full Text] [PDF] (IF= 4.411, (2010))

    • 49.Siva Sundara Kumar Durairajan, Qiuju Yuan, Lixia Xie, Wing-Sai Chan, Wan-Fung Kum, Irene Koo, Chenli Liu, Youqiang Song, Jian-Dong Huang *, William L. Klein, Min Li * (2008, Available online 16 September 2007) Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicty. Neurochemistry International, V52:741-750 [Abstract] [Full Text] [PDF] (* co-corresponding author) (IF=3.159, (2006)) doi:10.1016/j.neuint.2007.09.006

    • 50.Lin-Yu Lu, Michael S.Y. Huen, Andrew Chi-Pang Tai, De-pei Liu, Kathryn S.E. Cheah, and Jian-Dong Huang (February 2008) Optimization of single stranded oligonucleotide-mediated modification of plasmid DNA. BioTechniques, V44(2): 217-224 (IF= 2.550, (2010))

    • 51.Zai Wang, Zhong-Jun Zhou, De-Pei Liu, and Jian-Dong Huang (2008) Double-stranded break can be repaired by single-stranded oligonucleotides via the ATM/ATR pathway in mammalian cells. Oligonucleotides, V 18(1):21-32 [Abstract] [PDF] (Journal renamed as Nucleic Acid Therapeutics) (IF= 2.808, (2006))

    • 52.Zhi Li, Hong Yao, Yan Ma, Qingming Dong, Yangchao Chen, Ying Peng, Bo-jian Zheng, Jian-Dong Huang, Chu-yan Chan, Marie C. Lin, Joseph J. Sung, Kwok Yung Yuen, Hsiang-fu Kung, Ming-Liang He (March 31, 2008) Inhibition of HBV gene expression and replication by stably expressed interferon-α1 via adeno-associated viral vectors. Journal of Gene Medicine, V10(6):619-627. [Abstract] [Full Text] [PDF] (IF= 3.916)

    • 53.Jian-Dong Huang, Bojian Zheng, and Hongzhe Sun (August, 2008) Helicases as antiviral targets. Hong Kong Medical Journal, V14(4) Supplement 4:36-38

    • 54.Che-Man Chan, Patrick C. Y. Woo, Susanna K. P. Lau, Herman Tse, Hong-Lin Chen, Feng Li, Bo-Jian Zheng, Ling Chen, Jian-Dong Huang, and Kwok-Yung Yuen. (December, 2008, Epub ahead of print October 10, 2008) Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detection. Experimental Biology And Medicine V233(12):1527-36 [Abstract] [Full Text] [PDF] (IF= 2.954, (2010))

    • 55.Zhou, J., Smith, D.K., Lu, L., Poon, V.K.M., Ng, Fai., Chen, D.Q., Huang, J.D., Yuen, K.Y., Cao, K.Y., and Zheng, B.J. (January 2009, Epub August 28, 2008) A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic Hepatitis B Virus infection. Journal of Viral Hepatitis, V16(1):45-52. [Abstract] [Full Text] [PDF] (IF= 3.502, (2010))

    • 56.Che Man Chan, Susanna K. P. Lau, Patrick C. Y. Woo, Herman Tse, Bo-Jian Zheng, Ling Chen, Jian-Dong Huang, and Kwok-Yung Yuen (January 2009, Epub ahead of print November 5, 2008) Identification of Major Histocompatibility Antigen Class I C as an attachment factor that facilitates Coronavirus HKU1 Spike-mediated infection. Journal of Virology V83(2):1026-1035 [Abstract] [Full Text] [PDF] (IF= 5.332)

    • 57.Patrick C. Y. Woo, Susanna K. P. Lau, Herman Tse, Jade L. L. Teng, Shirly O. T. Curreem, Alan K. L. Tsang, Rachel Y. Y. Fan, Gilman K. M. Wong, Yi Huang, Nicholas J. Loman, Lori A. S. Snyder, James J. Cai, Jian-Dong Huang, William Mak, Mark J. Pallen, Si Lok, and Kwok-Yung Yuen (March 2009, Epub March 13, 2009) The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genetics. V5(3):e1000416 [Abstract] [Full Text] [PDF] (IF= 9.543, (2010))

    • 58.Ye Jin, Rory M. Watt, Antoine Danchin and Jian-Dong Huang (April 2009, Epub April 20, 2009) Small noncoding RNA GcvB is a novel regulator of acid resistance in Escherichia coli. BMC Genomics V10:165 [Abstract] [Full Text] [PDF] (IF= 4.206, (2010)). doi:10.1186/1471-2164-10-165

    • 59.Hong-Yan Sui, Guang-Yu Zhao, Jian-Dong Huang, Dong-Yan Jin, Kwok-Yung Yuen, Bo-Jian Zheng. (May 22, 2009) Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza A virus replication. PLoS ONE V4(5), e5671, [Abstract] [Full Text] [PDF] (IF= 4.411, (2010))

    • 60.Chan, C.M., Tse, H., Wong, S.S., Woo, P.C., Lau, S.K., Chen, .L, Zheng, B.J., Huang, J.D., and Yuen, K.Y. (May 2009, Epub ahead of print March 31, 2009) Examination of seroprevalence of coronavirus HKU1 infection with S protein-based ELISA and neutralization assay against viral spike pseudotyped virus. Journal of Clinical Virology V45(1):54-60, [Abstract] [Full Text] [PDF] (IF= 3.468)

    • 61.Jie Zhou*, Jian-Dong Huang*, Vincent K.M. Poon, Ding-Qiang Chen, Chris C.S. Chan, Fai Ng, Xin-Yuan Guan, Rory M. Watt, Liwei Lu, Kwok-Yung Yuen, Bo-Jian Zheng. (2009, Epub ahead of print May 3, 2009) Functional dissection of an IFN-α/β receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. Journal of Hepatology V51(2):322-332 (*Equal contribution) [Abstract] [Full Text] [PDF]. (IF= 6.642)

    • 62.Jie Zhou & Ding-Qiang Chen, Vincent K. M. Poon, Yong Zeng, Fai Ng, Liwei Lu, Jian-Dong Huang, Kwok-Yung Yuen & Bo-Jian Zheng. (June 2009, Epub ahead of print June 2, 2009) A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection. Immunogenetics V61(6):423-430, [Abstract] [Full Text] [PDF] (IF= 2.741) DOI 10.1007/s00251-009-0377-8

    • 63.Mingliang He, Bojian Zheng, Ying Chen, Wong, K.L., Jian-Dong Huang, Marie M.C. Lin, Kwok-Yung Yuen, Joseph J. Sung, and Hsing fu Kung. (June 2009) Development of interfering RNA agents to inhibit SARS-associated coronavirus infection and replication. Hong Kong Medical Journal V15(3) Supplement 4:28-31, [PDF]

    • 64.Chenli Liu, Zai Wang, Michael S.Y. Huen, Lin-Yu Lu, De-Pei Liu, and Jian-Dong Huang (2009, Epub ahead of print August 5, 2009) Cell death caused by single-stranded oligodeoxynucleotides mediated targeted genomic sequence modification. Oligonucleotides (Journal renamed as Nucleic Acid Therapeutics), V19(3):281-286 [Abstract] [PDF] (IF= 2.000, (2008))

    • 65.Muhan Chen, Jian-Dong Huang, Liang Hu, Bo-jian Zheng, Leilei Chen, Sze Lan Tsang, Xin-yuan Guan (August 24, 2009) Transgenic CHD1L expression in mouse induces spontaneous tumors. PLoS One V4(8):e6727, [Abstract] [Full Text] [PDF] (IF= 4.411, (2010))

    • 66.Ye Jin, Rory M. Watt, Antoine Danchin, and Jian-Dong Huang (October 16, 2009, Epub August 25, 2009) Use of a riboswitch-controlled conditional hypomorphic mutation to uncover a role for the essential CsrA gene in bacterial autoaggregation. Journal of Biological Chemistry, V284(42):28738-28745, [Abstract] [Full Text] [PDF] (IF=5.520, (2008))

    • 67.Jian-Dong Huang, Hongzhe Sun, Julian A. Tanner, and Rory M. Watt (October, 2009) Determine the functions of the putative metal-binding domain of SARS-CoV helicase. Hong Kong Medical Journal, V15(5) Supplement 6:15-16, [PDF]

    • 68.Ding-Qiang Chen, Yong Zeng, Jie Zhou, Ling Yang, Shibo Jiang, Jian-Dong Huang, Liwei Lu, and Bo-Jian Zheng (2010) Association of candidate susceptible loci with chronic hepatitis B virus infection in Chinese population. Journal of Medical Virology V82:371–378, [Abstract] [PDF] (IF= 2.895 (2010))

    • 69.Richard Y Kao, Dan Yang, Lai-Shan Lau, Wayne H W Tsui, Lihong Hu, Jun Dai, Mei-Po Chan, Che-Man Chan, Pui Wang, Bo-Jian Zheng, Jian Sun, Jian-Dong Huang, Jason Madar, Guanhua Chen, Honglin Chen, Yi Guan & Kwok-Yung Yuen (2010) Identification of influenza A nucleoprotein as an antiviral target. Nature Biotechnology V28, P600–605, [Abstract] [Full Text] [PDF] (IF= 31.085 (2010))

    • 70.Li Xia Xie, Siva Sundara Kumar Durairajan, Jia Hong Lu, Chen Li Liu, Wan Fung Kum, Yan Wang, Irene Koo, Wei Kang Wu, Dong Han, Fulong Lao, Jian-Dong Huang and Min Li. (2010) The effect of salvianolic acid B combined with laminar shear stress on TNF-?-stimulated adhesion molecule expression in human aortic endothelial cells. Clinical Hemorheology and Microcirculation, V44, P245–258 [Abstract] [Full Text] [PDF] (IF= 2.838, (2010))

    • 71.Liu Yang, Wing Sum Hui, Wilson C. W. Chan, Vivian C. W. Ng, Teresa H. Y. Yam, Helen C. M. Leung, Jian-Dong Huang, Daisy K. Y. Shum, Qiang Jie, Kenneth M. C. Cheung, Kathryn S. E. Cheah, Zhoujing Luo, Danny Chan (November, 2010, Article first published online: August 4, 2010) A splice site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas. Journal of Orthopaedic Research, V28(11), P1522-1530, [Abstract] [Full Text] [PDF] DOI 10.1002/jor.21162, (IF= 2.976, (2010))

    • 72.Ju Cui, Zai Wang, Qianni Cheng, Raozhou Lin, Xin-Mei Zhang, Po Sing Leung, Neal G. Copeland, Nancy A. Jenkins, Kwok-Ming Yao, and Jian-Dong Huang (January 2011, published ahead of print September 24, 2010) Targeted Inactivation of Kinesin-1 in Pancreatic β-Cells in vivo Leads to Insulin Secretory Deficiency. Diabetes V60(1), P320-330, [Abstract] [Full Text] [PDF] doi:10.2337/db09-1078, (IF= 8.889, (2010))

    • 73.Zai Wang, Jian-Dong Huang*, Kin-Ling Wong, Pei-Gang Wang, Hao-Jie Zhang, Julian A. Tanner, Ottavia Spiga, Andrea Bernini, Bo-Jian Zheng, Neri Niccolai * (January 2011, Article first published online: November 16, 2010, Epub 2010 Dec 6). On the mechanisms of bananin activity against SARS coronavirus. FEBS Journal V278, P383-389, (* co-corresponding author), [Abstract] [Full Text] [PDF] doi: 10.1111/j.1742-4658.2010.07961.x, (IF= 3.129, (2010))

    • 74.Jia-Hong Lu, Mustafa Taleb Ardah, Siva Sundara Kumar Durairajan, Liang-Feng Liu, Li-Xia Xie, Wang-Fun David Fong, Mohamed Y. Hasan, Jian-Dong Huang, Omar M. A. El-Agnaf, and Min Li (2011, Article first published online: January 26, 2011). Baicalein Inhibits Formation of a-Synuclein Oligomers within Living Cells and Prevents Ab Peptide Fibrillation and Oligomerisation. ChemBioChem V12, P615–624, [Abstract] [Full Text] [PDF] doi: 10.1002/cbic.201000604 (IF= 3.945, (2010))

    • 75.Siva Sundara Kumar Durairajan, Liang-Feng Liu, Jia-Hong Lu, Irene Koo, Kei Maruyama, Sookja K. Chung, Jian-Dong Huang* and Min Li* (2011 Mar 14. Epub ahead of print). Stimulation of Non-amyloidogenic Processing of Amyloid Precursor Protein by Cryptotanshinone Involves Activation and Translocation of ADAM-10 and PKC-alpha. Journal of Alzheimer's Disease V25, P245-262, (* co-corresponding author), [Abstract] [Full Text] [PDF] DOI 10.3233/JAD-2011-102085, (IF= 4.261, (2010))

    • 76.Wen-yang Chen, John W.S. Ho, Jian-Dong Huang, Rory M. Watt. (April 18, 2011) Functional characterization of an alkaline exonuclease and single strand annealing protein from the SXT genetic element of Vibrio cholerae. BMC Molecular Biology V12(1): 16, [Abstract] [Full Text] [PDF], doi:10.1186/1471-2199-12-16 (IF= 3.188, (2010))

    • 77.Bin Yu, Mei Yang, Ho Yin Bosco Wong, Rory M. Watt, Erwei Song, Bo-Jian Zheng, Kwok-yung Yuen, Jian-Dong Huang (May 25, 2011, Epub ahead of print) A method to generate recombinant Salmonella typhi Ty21a strains expressing multiple heterologous genes using an improved recombineering strategy. Applied Microbiology and Biotechnology V91(1), P177-188. [Abstract] [Full Text] [PDF], DOI 10.1007/s00253-011-3317-0 (IF= 3.280, (2010))

    • 78.Muhan Chen, Jian-Dong Huang, Hong Kui Deng, Suisui Dong, Wen Deng, Sze Lan Tsang, Michael S. Y. Huen, Leilei Chen, Tong Zan, Gui-Xia Zhu, Xin-Yuan Guan (May 26, 2011) Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. BMC Cancer V11:199, [Abstract] [Full Text] [PDF], doi:10.1186/1471-2407-11-199 (IF= 3.153, (2010))

    • 79.Ye Jin and Jian-Dong Huang (October 1, 2011, First published online: July 29, 2011) Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation. Nucleic Acids Research V39(19):e131 doi: 10.1093/nar/gkr609, (IF= 7.836, (2010))

    • 80.Song Lu, Lin-Yu Lu, Qiu-Ju Yuan, Mai-Har Sham, Xin-Yuan Guan, Jian-Dong Huang (August 10, 2011 Epub ahead of print, 2012) Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood. Neurobiology of Disease V45, P219–233, doi:10.1016/j.nbd.2011.08.006 (IF= 5.121, (2010))

    • 81.Wen Yang, Wen-yang Chen, Hui Wang, John W. S. Ho, Jian-Dong Huang, Patrick C. Y. Woo, Susanna K.P. Lau, Kwok-Yung Yuen, Qionglin Zhang, Weihong Zhou, Mark Bartlam, Rory M. Watt, and Zihe Rao, (September 5, 2011. Epub ahead of print) Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis. Nucleic Acids Research doi: 10.1093/nar/gkr660 (IF= 7.836, (2010))

    • 82.Mei Yang, Jingqi Chen, Fang Su, Bin Yu, Ling Lin, Yujie Liu, Jian-Dong Huang* and Erwei Song* (September 22, 2011 Epub ahead of print) Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Molecular Cancer V10(1):117 (*co-corresponding author) doi:10.1186/1476-4598-10-117 (IF= 3.779, (2010))

    • 83.Tim Hon Man Chan, Leilei Chen, Ming Liu, Liang Hu, Bo-jian Zheng, Vincent Kwok-Man Poon, Yun-Fei Yuan, Jian-dong Huang, Jie Yang, George Sai-wah Tsao, Xin-Yuan Guan, (February 2012, Epub ahead of print on September 27, 2011) Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. Hepatology V55(2):491-505 doi: 10.1002/hep.24709 (IF=10.840, (2009))

    • 84.Chenli Liu, Xiongfei Fu, Lizhong Liu, Xiaojing Ren, Carlos K.L. Chau, Sihong Li, Lu Xiang, Hualing Zeng, Guanhua Chen, Lei-Han Tang, Peter Lenz, Xiaodong Cui, Wei Huang*, Terence Hwa*, Jian-Dong Huang* (2011) Sequential establishment of stripe patterns in an expanding cell population. Science V334(6053), P238-241. (*co-corresponding author) DOI: 10.1126/science.1209042 (IF= 31.377, (2010))(Faculty of 1000 evaluations, dissents and comments for [Liu C et al. Sequential establishment of stripe patterns in an expanding cell population. Science.2011 Oct 14; 334(6053):238-41; doi: 10.1126/science.1209042]. Faculty of 1000, 12 Mar 2012. F1000.com/13985959)

    • 85.Qiuju Yuan, Huanxing Su, Jiasong Guo, Kwok Yeung Tsang, Kathryn S.E. Cheah, Kin Chiu, Jian Yang, Wai-Man Wong, Kwok-Fai So, Jian-Dong Huang, Wutian Wu, Zhi-xiu Lin, (April, 2012, Available online 22 February 2012) Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush. Experimental Gerontology V47(4), P329-36 (IF= 3.804, (2010))

    • 86.Siva Sundara Kumar Durairajan , Liang-Feng Liu, Jia-Hong Lu, Lei-Lei Chen, Qiuju Yuan, Sookja K. Chung, Ling Huang, Xing-Shu Li, Jian-Dong Huang* and Min Li*, (2012, Available online 27 March 2012) Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. Neurobiology of Aging (accepted) (*co-corresponding author). DOI: 10.1016/j.neurobiolaging.2012.02.016 (IF= 6.634, (2010))

    • 87.Xiongfei Fu, Lei-Han Tang, Chenli Liu, Jian-Dong Huang, Terence Hwa, and Peter Lenz (May 8, 2012) Stripe formation in bacterial systems with density-suppressed motility. Physical Review Letters. V108, 198102 (IF= 7.622, (2010))

    • 88.Bin Yu*, Mei Yang*, Lei Shi, Yandan Yao, Qinqin Jiang, Xuefei Li, Lei-Han Tang, Bo-Jian Zheng, Kwok-yung Yuen, David K. Smith, Erwei Song#, Jian-Dong Huang# (June 1, 2012) Explicit hypoxia targeting with tumor suppression by creating an “obligate” anaerobic Salmonella Typhimurium strain. Scientific Reports V2: 436 (*Equal contribution; # co-corresponding author) DOI: 10.1038/srep00436.